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KMID : 0653819860120020030
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Microorganisms and Industry
1986 Volume.12 No. 2 p.30 ~ p.35
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Molecular biological approaches to study the function and regulation of citrate synthase genes in saccharomyces cerevisiae
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Kim Kwang-Soo
Mark Rosankranz
Leonard Guarente
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Abstract
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Almost all of the aerobic organisms contain citric acid cycle (or, tricarboxylic acid cycle). This cycle is involved both in energy metabolism and biosynthetic reactions; generation of NADH which derives the synthesis of chemical energy, ATP, and provision of intermediates needed for the biosynthesis. Because of its importance in the cellular metabolism, the regulation of the TCA cycle and its component enzymes has been extensively studied by many biologists (7,28). Citrate synthase is resposible for the initial step of the cycle and has been recognized as the rate limiting step (14,121,26). Understanding of the mechanism of the expression of citrate synthase should be a key step for the elucidation of the regulation of the TCA cycle in the cell metabolism.
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KEYWORD
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